Cuddy: You’re afraid to be happy.
House: Why do you care if I’m happy?
Cuddy: [long pause] You’re afraid of change. The one thing you have is your intellect. You think if that’s compromised, you have nothing. Just take it.
Cuddy: Don’t do this.
House: It’s already done. This is the only me you get.
5.16 — “The Softer Side”
Cuddy: The only time you’re afraid is when you’re happy. You just don’t expect it to last.
House: ‘Cause it doesn’t.
Cuddy: You don’t know that.
House: I’ve done horrible things to you. And I’ll do horrible things again to you. But because of one stupid moment with a dying girl and a pile of rubble you think I can change. Tell me where I’m wrong.
Cuddy: I don’t want you to change. I know you’re screwed up. I know you are always gonna be screwed up. But you’re the most incredible man I’ve ever known. You are always gonna be the most incredible man I have ever known.
7.01 — “Now What?”
I’ve always felt that one of the things that makes Cuddy’s relationship with House stand out from anyone else on the show is that she has never expected him to change. With Cameron and Wilson, and even Stacy to a certain extent, this need to change House, to make him “a better person”, has always been prevalent and yet Cuddy has always accepted [and loved] him for who he is, flaws and all, and i find that beautiful. He may have thought that she wanted him to change, but in reality the only thing she ever wanted was for him to be happy and that makes all the difference in the world.